The plasticity of primary motor cortex (M1) in patients with Parkinson's disease (PD) and
levodopa-induced dyskinesias (LIDs) is severely impaired. We recently reported in young
healthy subjects that inhibitory cerebellar stimulation enhanced the sensorimotor plasticity of
M1 that was induced by paired associative stimulation (PAS). This study demonstrates that
the deficient sensorimotor M1 plasticity in 16 patients with LIDs could be reinstated by a
single session of real inhibitory cerebellar stimulation but not sham stimulation. This was …

Introduction The plasticity of primary motor cortex (M1) in patients with Parkinson's disease
(PD) and levodopa-induced dyskinesias (LIDs) is severely impaired (Morgante, 2006,
Kishore, 2012). We reported that inhibitory cerebellar stimulation with continuous theta burst
stimulation (cTBS) enhanced the sensori-motor plasticity of M1 induced by paired
associative stimulation (PAS) in healthy subjects (Popa, 2012). Koch (2009) demonstrated a
beneficial effect on LIDs of repeated sessions of cTBS to the cerebellum. Objectives To find …