The halal industry continues to grow in various parts of the world, including Indonesia. It is currently one of the most potential economic sectors. However, despite having very good prospects, the halal industry also faces several challenges in the 5.0 era, especially in the fields of science and Islamic laws. For this reason, this research was conducted to reveal the challenges of the halal industry in Indonesia. The research method used is library research whose sources are from the Quran, hadiths, books, laws and regulations, and scientific articles. The research reveals that in terms of science, the challenges include the supply chain, and raw materials used in the production process. In addition, raw materials that were originally halal but due to a lack of public understanding, the final product becomes haram, either due to the slaughtering process or other processes. The next challenge is the use of food and beverage names, equipment, storage tools, and digital business processes. Meanwhile, from the Islamic law perspective, all processes in the halal industry must be by Islamic values found in the Quran, hadith, and the opinions of scholars. In addition, the next challenge is to develop modern halal fiqh that reaches aspects of artificial intelligence 5.0.