Changes in the content of estrogen α and progesterone receptors during differentiation of mouse embryonic stem cells to dopamine neurons
NF Díaz, C Guerra-Arraiza, NE Díaz-Martínez… - Brain research …, 2007 - Elsevier
Embryonic stem cells (ESC) can differentiate to derivatives of the three embryonic germ
layers. Dopamine neurons have been produced from mouse and human ESC. This in vitro
induction mimics the developmental program followed by dopaminergic cells in vivo.
Production of dopamine neurons might have clinical applications for Parkinson's disease,
which has a higher incidence in men than in women, suggesting a protective role for sex
hormones, particularly progesterone and estradiol. These hormones exert many of their …
layers. Dopamine neurons have been produced from mouse and human ESC. This in vitro
induction mimics the developmental program followed by dopaminergic cells in vivo.
Production of dopamine neurons might have clinical applications for Parkinson's disease,
which has a higher incidence in men than in women, suggesting a protective role for sex
hormones, particularly progesterone and estradiol. These hormones exert many of their …
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