Characterisation of Nuclear Architectural Alterations during In Vitro Differentiation of Human Stem Cells of Myogenic Origin
N Rozwadowska, T Kolanowski, E Wiland… - PloS one, 2013 - journals.plos.org
Cell differentiation is based on a synchronised orchestra of complex pathways of intrinsic
and extrinsic signals that manifest in the induced expression of specific transcription factors
and pivotal genes within the nucleus. One cannot ignore the epigenetic status of
differentiating cells, comprising not only histones and DNA modifications but also the spatial
and temporal intranuclear chromatin organisation, which is an important regulator of nuclear
processes. In the present study, we investigated the nuclear architecture of human primary …
and extrinsic signals that manifest in the induced expression of specific transcription factors
and pivotal genes within the nucleus. One cannot ignore the epigenetic status of
differentiating cells, comprising not only histones and DNA modifications but also the spatial
and temporal intranuclear chromatin organisation, which is an important regulator of nuclear
processes. In the present study, we investigated the nuclear architecture of human primary …
[PDF][PDF] Characterisation of Nuclear Architectural Alterations during In Vitro
N Rozwadowska, T Kolanowski, E Wiland… - 2013 - researchgate.net
Cell differentiation is based on a synchronised orchestra of complex pathways of intrinsic
and extrinsic signals that manifest in the induced expression of specific transcription factors
and pivotal genes within the nucleus. One cannot ignore the epigenetic status of
differentiating cells, comprising not only histones and DNA modifications but also the spatial
and temporal intranuclear chromatin organisation, which is an important regulator of nuclear
processes. In the present study, we investigated the nuclear architecture of human primary …
and extrinsic signals that manifest in the induced expression of specific transcription factors
and pivotal genes within the nucleus. One cannot ignore the epigenetic status of
differentiating cells, comprising not only histones and DNA modifications but also the spatial
and temporal intranuclear chromatin organisation, which is an important regulator of nuclear
processes. In the present study, we investigated the nuclear architecture of human primary …