Characterization, kinetics, and crystal structures of fructose-1, 6-bisphosphate aldolase from the human parasite, Giardia lamblia
Class I and class II fructose-1, 6-bisphosphate aldolases (FBPA), glycolytic pathway
enzymes, exhibit no amino acid sequence homology and utilize two different catalytic
mechanisms. The mammalian class I FBPA employs a Schiff base mechanism, whereas the
human parasitic protozoan Giardia lamblia class II FBPA is a zinc-dependent enzyme. In this
study, we have explored the potential exploitation of the Giardia FBPA as a drug target. First,
synthesis of FBPA was demonstrated in Giardia trophozoites by using an antibody-based …
enzymes, exhibit no amino acid sequence homology and utilize two different catalytic
mechanisms. The mammalian class I FBPA employs a Schiff base mechanism, whereas the
human parasitic protozoan Giardia lamblia class II FBPA is a zinc-dependent enzyme. In this
study, we have explored the potential exploitation of the Giardia FBPA as a drug target. First,
synthesis of FBPA was demonstrated in Giardia trophozoites by using an antibody-based …
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