The encapsulation of vitamin E using combined solution of maltodextrin and sodium caseinate by spray-drying technique was investigated. Spray drying is the most commonly used method in the food industry. The physical characterizations of the encapsulated vitamin E gave valuable information on the surface morphology, size, shape, solubility, and moisture content. The micrograph of the vitamin E microcapsules indicated that the feed composition affects the morphology of the product. The particle sizes measured were ranging from 13 to with moderate moisture contents (4.5–4.98%) and were not affected by the amount of oil and type of wall material used. The solubility test indicated that there is a relationship between the amount of maltodextrin in formulations and the solubility. The microcapsule was considered soluble since the solubility time was obtained from 178 to 251 s.