Characterization of the MRP4-and MRP5-mediated transport of cyclic nucleotides from intact cells
PR Wielinga, I van der Heijden, G Reid… - Journal of Biological …, 2003 - ASBMB
Cyclic nucleotides are known to be effluxed from cultured cells or isolated tissues. Two
recently described members of the multidrug resistance protein family, MRP4 and MRP5,
might be involved in this process, because they transport the 3′, 5′-cyclic nucleotides,
cAMP and cGMP, into inside-out membrane vesicles. We have investigated cGMP and
cAMP efflux from intact HEK293 cells overexpressing MRP4 or MRP5. The intracellular
production of cGMP and cAMP was stimulated with the nitric oxide releasing compound …
recently described members of the multidrug resistance protein family, MRP4 and MRP5,
might be involved in this process, because they transport the 3′, 5′-cyclic nucleotides,
cAMP and cGMP, into inside-out membrane vesicles. We have investigated cGMP and
cAMP efflux from intact HEK293 cells overexpressing MRP4 or MRP5. The intracellular
production of cGMP and cAMP was stimulated with the nitric oxide releasing compound …
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