System L is a major nutrient transport system responsible for the Na+-independent transport
of large neutral amino acids including several essential amino acids. In malignant tumors, a
system L transporter L-type amino acid transporter 1 (LAT1) is up-regulated to support tumor
cell growth. LAT1 is also essential for the permeation of amino acids and amino acid-related
drugs through the blood–brain barrier. To search for in vitro assay systems to examine the
interaction of chemical compounds with LAT1, we have investigated the expression of …

Characterization of the system L amino acid transporter in T24 human bladder carcinoma
cells | CiNii Research … Characterization of the system L amino acid transporter in T24
human bladder carcinoma cells …