Characterization of tumor cell lines derived from murine gammaherpesvirus-68-infected mice
EJ Usherwood, JP Stewart, AA Nash - Journal of virology, 1996 - Am Soc Microbiol
EJ Usherwood, JP Stewart, AA Nash
Journal of virology, 1996•Am Soc MicrobiolCell lines were derived from mice with murine gammaherpesvirus-68 (MHV-68)-associated
lymphoproliferative disease. Four were of an ambiguous phenotype and were MHV-68
negative. One, S11, was a B lymphocyte that contained MHV-68 genomes in both linear and
episomal forms and released virus. The line was clonable and grew into tumors in nude
mice. This is the first naturally occurring MHV-68-positive B-cell line to be generated, and it
will be an invaluable tool for the study of MHV-68 latency.
lymphoproliferative disease. Four were of an ambiguous phenotype and were MHV-68
negative. One, S11, was a B lymphocyte that contained MHV-68 genomes in both linear and
episomal forms and released virus. The line was clonable and grew into tumors in nude
mice. This is the first naturally occurring MHV-68-positive B-cell line to be generated, and it
will be an invaluable tool for the study of MHV-68 latency.
Cell lines were derived from mice with murine gammaherpesvirus-68 (MHV-68)-associated lymphoproliferative disease. Four were of an ambiguous phenotype and were MHV-68 negative. One, S11, was a B lymphocyte that contained MHV-68 genomes in both linear and episomal forms and released virus. The line was clonable and grew into tumors in nude mice. This is the first naturally occurring MHV-68-positive B-cell line to be generated, and it will be an invaluable tool for the study of MHV-68 latency.
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