Characterizing solution surface loop conformational flexibility of the GM2 activator protein
JD Carter, JD Mathias, EF Gomez, Y Ran… - The Journal of …, 2014 - ACS Publications
GM2AP has a β-cup topology with numerous X-ray structures showing multiple
conformations for some of the surface loops, revealing conformational flexibility that may be
related to function, where function is defined as either membrane binding associated with
ligand binding and extraction or interaction with other proteins. Here, site-directed spin
labeling (SDSL) electron paramagnetic resonance (EPR) spectroscopy and molecular
dynamic (MD) simulations are used to characterize the mobility and conformational flexibility …
conformations for some of the surface loops, revealing conformational flexibility that may be
related to function, where function is defined as either membrane binding associated with
ligand binding and extraction or interaction with other proteins. Here, site-directed spin
labeling (SDSL) electron paramagnetic resonance (EPR) spectroscopy and molecular
dynamic (MD) simulations are used to characterize the mobility and conformational flexibility …
[引用][C] Characterizing Solution Surface Loop Conformational Flexibility of the GM2 Activator Protein
R Yong, X Fang, G Luis, W D'Amore Peter - 2014
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