Male breast cancer (MBC) is rare and poorly characterized. Like the female counterpart,
most MBCs are hormonally driven, but relapse after hormonal treatment is also noted. The
pan-hormonal action of steroid hormonal receptors, including estrogen receptor alpha
(ERα), androgen receptor (AR), progesterone receptor (PR), and glucocorticoid receptor
(GR) in this understudied tumor type remains wholly unexamined. This study reveals
genomic cross-talk of steroid hormone receptor action and interplay in human tumors, here …