Chelator-free radiolabeling of dextran with 68Ga for PET studies
N Gholipour, M Akhlaghi, AM Kheirabadi… - … of Radioanalytical and …, 2017 - Springer
Journal of Radioanalytical and Nuclear Chemistry, 2017•Springer
The possibility of 68 Ga-dextran complex formation was analyzed in an HEPES-buffered
(pH= 4.5) as well as in an alkaline (pH= 9) solution. The result outlined that the alkaline
solution was more efficient to achieve a radiolabeling efficiency of 99% for a 5 mg ml− 1
dextran solution (10 min, 90 C). 68 Ga-dextran was stable 88, 71 and 86% after 2 h at
storage and toward cysteine solution and human serum, respectively. The highest ROI
derived% ID g− 1 was found within the lungs, followed by the blood, liver, and bladder …
(pH= 4.5) as well as in an alkaline (pH= 9) solution. The result outlined that the alkaline
solution was more efficient to achieve a radiolabeling efficiency of 99% for a 5 mg ml− 1
dextran solution (10 min, 90 C). 68 Ga-dextran was stable 88, 71 and 86% after 2 h at
storage and toward cysteine solution and human serum, respectively. The highest ROI
derived% ID g− 1 was found within the lungs, followed by the blood, liver, and bladder …
Abstract
The possibility of 68 Ga-dextran complex formation was analyzed in an HEPES-buffered (pH= 4.5) as well as in an alkaline (pH= 9) solution. The result outlined that the alkaline solution was more efficient to achieve a radiolabeling efficiency of 99% for a 5 mg ml− 1 dextran solution (10 min, 90 C). 68 Ga-dextran was stable 88, 71 and 86% after 2 h at storage and toward cysteine solution and human serum, respectively. The highest ROI derived% ID g− 1 was found within the lungs, followed by the blood, liver, and bladder. Furthermore, a significant uptake was observed in the cartilage tissue. 68 Ga-dextran excreted more by the urinary and less by the biliary pathways.
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