Chemopreventive potential of chrysin in 7, 12-dimethylbenz (a) anthracene-induced hamster buccal pouch carcinogenesis

S Karthikeyan, R Srinivasan, SA Wani… - … Journal of Nutrition …, 2013 - journals.lww.com
Materials and Methods: Oral squamous cell carcinoma was developed in the buccal pouch
of Syrian golden hamsters by painting them with 0.5 percent DMBA in liquid paraffin thrice a
week, for 14 weeks. The status of lipid peroxidation, antioxidants, and phase I and II
detoxification agents were utilized as biochemical end points, to assess the
chemopreventive efficacy of chrysin in DMBA-induced hamster buccal pouch
carcinogenesis. Results: In the present study, 100% tumor formation with marked …
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