In solid tumors, elevated fluid pressure and inadequate blood perfusion resulting from
unbalanced angiogenesis are the prominent reasons for the ineffective drug delivery inside
tumors. To normalize the heterogeneous and tortuous tumor vessel structure, antiangiogenic
treatment is an effective approach. Additionally, the combined therapy of antiangiogenic
agents and chemotherapy drugs has shown promising effects on enhanced drug delivery.
However, the need to find the appropriate scheduling and dosages of the combination …

< jats: title> Abstract</jats: title>< jats: p> In solid tumors, elevated fluid pressure and
inadequate blood perfusion resulting from unbalanced angiogenesis are the prominent
reasons for the ineffective drug delivery inside tumors. To normalize the heterogeneous and
tortuous tumor vessel structure, antiangiogenic treatment is an effective approach.
Additionally, the combined therapy of antiangiogenic agents and chemotherapy drugs has
shown promising effects on enhanced drug delivery. However, the need to find the …