Chloroplast targeting of phytochelatin synthase in Arabidopsis: effects on heavy metal tolerance and accumulation

N Picault, AC Cazalé, A Beyly, S Cuiné, P Carrier… - Biochimie, 2006 - Elsevier
The enzymatically synthesized thiol peptide phytochelatin (PC) plays a central role in heavy
metal tolerance and detoxification in plants. In response to heavy metal exposure, the
constitutively expressed phytochelatin synthase enzyme (PCS) is activated leading to
synthesis of PCs in the cytosol. Recent attempts to increase plant metal accumulation and
tolerance reported that PCS over-expression in transgenic plants paradoxically induced
cadmium hypersensitivity. In the present paper, we investigate the possibility of synthesizing …
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