Chromosomal DNA deletion confers phage resistance to Pseudomonas aeruginosa
S Le, X Yao, S Lu, Y Tan, X Rao, M Li, X Jin, J Wang… - Scientific reports, 2014 - nature.com
Bacteria develop a broad range of phage resistance mechanisms, such as prevention of
phage adsorption and CRISPR/Cas system, to survive phage predation. In this study,
Pseudomonas aeruginosa PA1 strain was infected with lytic phage PaP1 and phage-
resistant mutants were selected. A high percentage (~ 30%) of these mutants displayed red
pigmentation phenotype (Red mutant). Through comparative genomic analysis, one Red
mutant PA1r was found to have a 219.6 kb genomic fragment deletion, which contains two …
phage adsorption and CRISPR/Cas system, to survive phage predation. In this study,
Pseudomonas aeruginosa PA1 strain was infected with lytic phage PaP1 and phage-
resistant mutants were selected. A high percentage (~ 30%) of these mutants displayed red
pigmentation phenotype (Red mutant). Through comparative genomic analysis, one Red
mutant PA1r was found to have a 219.6 kb genomic fragment deletion, which contains two …
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