The recent advances in DNA sequencing technology are enabling a rapid increase in the
number of genomes being sequenced. However, many fundamental questions in genome
biology remain unanswered, because sequence data alone is unable to provide insight into
how the genome is organised into chromosomes, the position and interaction of those
chromosomes in the cell, and how chromosomes and their interactions with each other
change in response to environmental stimuli or over time. The intimate relationship between …