Circadian rhythms: move over neurons—astrocytes mediate SCN clock function
MD Ruben, JB Hogenesch - Current Biology, 2017 - cell.com
Current Biology, 2017•cell.com
… While clock function in SCN neurons is required for behavioral rhythmicity, on its own it is not
sufficient to produce normal circadian rhythms. Conversely, while … Maybe just as importantly,
these three new studies above apply genetic tools to visualize and edit the astrocyte
molecular oscillator with unprecedented precision. While pan-tissue reporters of clock function
have been critical to our understanding of circadian rhythms in the SCN and elsewhere [ …
sufficient to produce normal circadian rhythms. Conversely, while … Maybe just as importantly,
these three new studies above apply genetic tools to visualize and edit the astrocyte
molecular oscillator with unprecedented precision. While pan-tissue reporters of clock function
have been critical to our understanding of circadian rhythms in the SCN and elsewhere [ …
Summary
Neurons in the suprachiasmatic nuclei (SCN) of the hypothalamus are described as master pacemaker cells for biological rhythms. However, a series of recent studies demonstrate the importance of another cell type, astrocytes, for biological timekeeping.
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