Circulating levels of specific members of chromosome 19 microRNA cluster are associated with preeclampsia development
ML Martinez-Fierro, I Garza-Veloz… - Archives of gynecology …, 2018 - Springer
Archives of gynecology and obstetrics, 2018•Springer
Purpose To perform serum microRNA expression profiling to identify members of
chromosome 19 miRNA cluster involved in preeclampsia development. Methods Serum
chromosome 19 miRNA cluster microRNA expression profiling was evaluated at 12, 16, and
20 gestational weeks and at the time of preeclampsia diagnosis, in women who developed
preeclampsia (WWD-PE; n= 16) and controls (n= 18) using TaqMan low density array plates.
Results A total of 51 chromosome 19 microRNA cluster members were evaluated. The …
chromosome 19 miRNA cluster involved in preeclampsia development. Methods Serum
chromosome 19 miRNA cluster microRNA expression profiling was evaluated at 12, 16, and
20 gestational weeks and at the time of preeclampsia diagnosis, in women who developed
preeclampsia (WWD-PE; n= 16) and controls (n= 18) using TaqMan low density array plates.
Results A total of 51 chromosome 19 microRNA cluster members were evaluated. The …
Purpose
To perform serum microRNA expression profiling to identify members of chromosome 19 miRNA cluster involved in preeclampsia development.
Methods
Serum chromosome 19 miRNA cluster microRNA expression profiling was evaluated at 12, 16, and 20 gestational weeks and at the time of preeclampsia diagnosis, in women who developed preeclampsia (WWD-PE; n = 16) and controls (n = 18) using TaqMan low density array plates.
Results
A total of 51 chromosome 19 microRNA cluster members were evaluated. The circulating hsa-miRs 512-3p, 518f-3p, 520c-3p, and 520d-3p, were differentially expressed between groups (P < 0.05). Compared with controls, serum levels of hsa-miR-518f-3p at 20 GW were useful for identifying WWD-Mild-PE (P = 0.035) and WWD-Severe-PE (P = 0.007).
Conclusions
Serum hsa-miRs 512-3p, 518f-3p, 520c-3p, and 520d-3p, are differentially expressed between WWD-PE and controls and their role in the development of preeclampsia should be investigated further.
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