Cryo-electron tomography (CET) is currently the only three-dimensional imaging technique
capable of visualizing macromolecules in their cellular context at close-to-native conditions
with a resolution in the nanometer range. An important component for the analysis of the
data is their classification, which should discriminate among various macromolecules,
conformational changes and interaction partners. Missing structure factors, typically in a
wedge-shaped region in Fourier space if single-axis tilting is performed, hamper …