[PDF][PDF] Clinical and laboratory characteristics of children referred for early puberty: preponderance in 7-8 years of age

A Kılıç, MS Durmuş, E Ünüvar, İ Yıldız… - Journal of clinical …, 2012 - jag.journalagent.com
A Kılıç, MS Durmuş, E Ünüvar, İ Yıldız, BK Aydın, A Uçar, R Bundak, F Baş, F Darendeliler…
Journal of clinical research in pediatric endocrinology, 2012jag.journalagent.com
Ob jec ti ve: The aim of this study was to evaluate the girls referred to the pediatric outpatient
clinic with a presumptive diagnosis of early puberty due to early onset of breast development
or pubarche. Methods: Within the study period, we evaluated 289 subjects referred for
concerns about early onset of puberty. History, anthropometric data, bone age (BA),
hormones including luteinizing hormone (LH), follicle-stimulating hormone (FSH), estradiol,
and dehydroepiandrosterone sulfate, as well as pelvic ultrasonography (USG)-derived …
Ob jec ti ve
The aim of this study was to evaluate the girls referred to the pediatric outpatient clinic with a presumptive diagnosis of early puberty due to early onset of breast development or pubarche.
Methods
Within the study period, we evaluated 289 subjects referred for concerns about early onset of puberty. History, anthropometric data, bone age (BA), hormones including luteinizing hormone (LH), follicle-stimulating hormone (FSH), estradiol, and dehydroepiandrosterone sulfate, as well as pelvic ultrasonography (USG)-derived ovarian and uterine volumes were analyzed.
Results
Of the 289 girls referred for early onset of pubertal development, 64 (22.1%) had false alarms for puberty. Of the remaining 225 girls, 41 (18.2%) were diagnosed as premature pubarche, 56 (24.9%) as premature thelarche (PT), and 128 (56.9%) as precocious puberty (PP). Girls with earlyonset puberty had more advanced BA, greater uterine and ovarian volumes, and also higher LH values than subjects with PP and PT. Nearly half of these girls were 7-8 years of age. Body mass index (BMI) standard deviation score was significantly higher in the PP cases.
Conclusions
There is a need for primary care physicians to be more knowledgeable on puberty and on puberty problems. There seems to be a preponderance of PP in 7-8-year-old children. Increased BMI may have a role in the trend towards earlier onset of puberty
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