mutations of BRCA1 have distinct clinical and pathological features as compared with
sporadic ovarian cancers. Methods We reviewed clinical and pathological data on patients
with primary epithelial ovarian cancer found to have germ-line mutations of BRCA1. Survival
among patients with advanced-stage cancer and such mutations was compared with that in
control patients matched for age and stage, grade, and histologic subtype of the tumors. A …