过去一年中添加的文章，按日期排序
[HTML][HTML] Nonopioid analgesics discovery and the Valley of Death:...: PAIN
H To's - reliefinstitute.com
8 天前 - … to placebo in early phase clinical trials. 121,124 Examples of “failed” novel analgesics
include neurokinin-1 receptor antagonists, 99 chemokine receptor-2 antagonists, 44 fatty …
include neurokinin-1 receptor antagonists, 99 chemokine receptor-2 antagonists, 44 fatty …
Binding of interleukin-1 receptor antagonist to cholinergic receptor muscarinic 4 promotes immunosuppression and neuroendocrine differentiation in prostate cancer
YN Liu, MK Liu, YC Wen, CH Li, HL Yeh, PVT Dung… - Cancer Letters, 2024 - Elsevier
21 天前 - … chemokines. This creates a hostile immune landscape that impedes effective immune
responses. The interleukin-1 (IL-1) receptor antagonist (… To assess the clinical implications…
responses. The interleukin-1 (IL-1) receptor antagonist (… To assess the clinical implications…
Development of a NanoBRET Assay Platform to Detect Intracellular Ligands for the Chemokine Receptors CCR6 and CXCR1
ME Huber, SL Wurnig, AFA Moumbock, L Toy… - …, 2024 - Wiley Online Library
22 天前 - … [18e] For the highly potent CCR6 antagonist 2,[18d] currently in phase I clinical
trials for ulcerative colitis, we detected a very strong competition, thus clearly indicating binding …
trials for ulcerative colitis, we detected a very strong competition, thus clearly indicating binding …
THE ROLE OF THE TWEAK/Fn14 AXIS IN THE TNF-α-INDUCED PATHOGENESIS OF RHEUMATOID ARTHRITIS
F Shaikh - rex.libraries.wsu.edu
23 天前 - … (RASFs) to promote the secretion of chemokines and adhesion molecules,
enhancing the … Interestingly, our clinical sample analysis revealed differential TWEAK levels in …
enhancing the … Interestingly, our clinical sample analysis revealed differential TWEAK levels in …
AB0706 CIRCULATING HELPER T AND INNATE LYMPHOID CELLS IN A COHORT OF bDMARDs-NAÏVE PATIENTS WITH RHEUMATOID ARTHRITIS TREATED …
P Semeraro, F Angeli, A Caproli, F Franceschini, P Airo… - 2024 - ard.bmj.com
48 天前 - … We collected clinical parameters including disease … , we hypothesized that its
blocker abatacept (ABA) might … , which is the main chemokine receptor of Th17 and Th17-…
blocker abatacept (ABA) might … , which is the main chemokine receptor of Th17 and Th17-…
PET Imaging of CXCR4 Expression Using [18F] AlF-NOTA-QHY-04 for Solid Tumors and Hematologic Malignancy
S Xu, J Liu, J Yu - 2024 - Soc Nuclear Med
48 天前 - … through both preclinical and pilot clinical studies.CXC motif chemokine receptor 4
(CXCR4) is … based on a potent CXCR4 peptide antagonist, and evaluated by cellular uptake, …
(CXCR4) is … based on a potent CXCR4 peptide antagonist, and evaluated by cellular uptake, …
Proteomic analysis in patients with dedifferentiated liposarcoma (DDLPS) in a phase Ia/Ib study of the MDM2–p53 antagonist brigimadlin.
Y Jaimes, P LoRusso, G Sturm, MM Gounder… - 2024 - ascopubs.org
51 天前 - … Both preclinical and clinical studies have demonstrated that restoring p53 activity
… At baseline, angiopoietin-1, CC motif chemokine 16, PAI-1, and CC motif chemokine 5 were …
… At baseline, angiopoietin-1, CC motif chemokine 16, PAI-1, and CC motif chemokine 5 were …
Characterization of the tumor microenvironment after combined radio-and immunotherapy in a murine glioblastoma model
B Link - 2024 - archiv.ub.uni-heidelberg.de
52 天前 - … CXC-motive chemokine ligand x CXCRx CXC motif chemokine receptor x D50 …
and the chemokine receptor CCR2 is very high. The blocking of CCR2 significantly reduces the …
and the chemokine receptor CCR2 is very high. The blocking of CCR2 significantly reduces the …
# 1166 ACTION3 pivotal Phase 3 & open-label extension study assessing DMX-200 in adult & paediatric patients with focal segmental glomerulosclerosis (FSGS)
57 天前 - … DMX-200 (repagermanium) is a CC motif chemokine receptor … -200 and the
angiotensin receptor blocker (ARB) irbesartan … No clinically significant safety concerns have been …
angiotensin receptor blocker (ARB) irbesartan … No clinically significant safety concerns have been …
Tetrahydroisoquinoline-Based Small Molecule Inhibitors of the Chemokine Receptor CXCR4
74 天前 - … CXCR4 is a physiologically important chemokine receptor that is expressed on …
CXCR4 antagonists will continue to be progressed through the pre-clinical pipeline and …
CXCR4 antagonists will continue to be progressed through the pre-clinical pipeline and …