Clinically driven design of multi-scale cancer models: the ContraCancrum project paradigm

K Marias, D Dionysiou, V Sakkalis, N Graf… - Interface …, 2011 - royalsocietypublishing.org
… to describe a novel paradigm for designing clinically driven multi-scale cancer modelling by
multi-scale tumour modelling components has led to novel concepts of personalized clinical

[HTML][HTML] Navigating multi-scale cancer systems biology towards model-driven clinical oncology and its applications in personalized therapeutics

MN Gondal, SU Chaudhary - Frontiers in Oncology, 2021 - frontiersin.org
… an intuitive framework modeling paradigm, the … ContraCancrum aimed to construct a
multi-scale computational framework for translating personalized cancer models into clinical

Navigating Multi-scale Cancer Systems Biology towards Model-driven Personalized Therapeutics

MN Gondal, SU Chaudhary - bioRxiv, 2021 - biorxiv.org
… an intuitive framework modeling paradigm, however, … ContraCancrum aimed to develop
a multi-scale computational framework for translating personalized cancer models into clinical

The technologically integrated oncosimulator: combining multiscale cancer modeling with information technology in the in silico oncology context

G Stamatakos, D Dionysiou, A Lunzer… - IEEE Journal of …, 2013 - ieeexplore.ieee.org
… , a number of combined multiscale modeling and information … , a clinical adaptation paradigm
of the breast cancer branch … two EC projects on cancer modeling (ContraCancrum and TU…

Integrating multiscale modeling with drug effects for cancer treatment

XL Li, WO Oduola, L Qian… - Cancer …, 2015 - journals.sagepub.com
… The need for a paradigm shift to the integration of multi-scale modelsContraCancrum
project paradigm 74–82 has been focused on clinically driven design of multiscale cancer models

IMENSE: An e-infrastructure environment for patient specific multiscale data integration, modelling and clinical treatment

SJ Zasada, T Wang, A Haidar, E Liu, N Graf… - Journal of …, 2012 - Elsevier
ContraCancrum has complex computational needs, with the multi-scale models developed
by the project … , is nevertheless a paradigm of the ICT infrastructures required to support …

[HTML][HTML] Multi-scale network targeting: A holistic systems-biology approach to cancer treatment

D Paul, NL Komarova - Progress in biophysics and molecular biology, 2021 - Elsevier
… The model of cancer as a multidimensional spatio-temporal network … multi-scale interventions
may represent a paradigm shift that may guide the way we understand and treat cancer in …

[HTML][HTML] The INTEGRATE project: delivering solutions for efficient multi-centric clinical research and trials

H Kondylakis, B Claerhout, M Keyur, L Koumakis… - Journal of biomedical …, 2016 - Elsevier
… of multi-scale biomedical data in the context of post-genomic clinical trials, the development
of predictive models … execution of postgenomic multi-centric clinical trials in breast cancer. …

Mathematical Oncology to Cancer Systems Medicine: Translation from Academic Pursuit to Individualized Therapy with MORA

D Majumder - Current Cancer Therapy Reviews, 2023 - ingentaconnect.com
Clinically Driven Models Multi-scale cancer model was designed using clinical data from
non-small cell lung cancer and glioblastoma by bringing together basic science and …

Article Commentary: Dealing with Diversity in Computational Cancer Modeling

D Johnson, S McKeever, G Stamatakos… - Cancer …, 2013 - journals.sagepub.com
… The two types of techniques can be combined to possibly increase the accuracy of clinically
relevant models such as those exploited by the VPH projects (ACGT, ContraCancrum) and …