Clostridium difficile has two parallel and essential Sec secretion systems
RP Fagan, NF Fairweather - Journal of Biological Chemistry, 2011 - ASBMB
Protein translocation across the cytoplasmic membrane is an essential process in all
bacteria. The Sec system, comprising at its core an ATPase, SecA, and a membrane
channel, SecYEG, is responsible for the majority of this protein transport. Recently, a second
parallel Sec system has been described in a number of Gram-positive species. This
accessory Sec system is characterized by the presence of a second copy of the energizing
ATPase, SecA2; where it has been studied, SecA2 is responsible for the translocation of a …
bacteria. The Sec system, comprising at its core an ATPase, SecA, and a membrane
channel, SecYEG, is responsible for the majority of this protein transport. Recently, a second
parallel Sec system has been described in a number of Gram-positive species. This
accessory Sec system is characterized by the presence of a second copy of the energizing
ATPase, SecA2; where it has been studied, SecA2 is responsible for the translocation of a …
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