Clostridium scindens secretome suppresses virulence gene expression of Clostridioides difficile in a bile acid-independent manner
C Saenz, Q Fang, T Gnanasekaran… - Microbiology …, 2023 - Am Soc Microbiol
Clostridioides difficile infection (CDI) is a major health concern and one of the leading
causes of hospital-acquired diarrhea in many countries. C. difficile infection is challenging to
treat as C. difficile is resistant to multiple antibiotics. Alternative solutions are needed as
conventional treatment with broad-spectrum antibiotics often leads to recurrent CDI. Recent
studies have shown that specific microbiota-based therapeutics such as bile acids (BAs) are
promising approaches to treat CDI. Clostridium scindens encodes the bile acid-induced …
causes of hospital-acquired diarrhea in many countries. C. difficile infection is challenging to
treat as C. difficile is resistant to multiple antibiotics. Alternative solutions are needed as
conventional treatment with broad-spectrum antibiotics often leads to recurrent CDI. Recent
studies have shown that specific microbiota-based therapeutics such as bile acids (BAs) are
promising approaches to treat CDI. Clostridium scindens encodes the bile acid-induced …
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