Coenzyme q10 prevents apoptosis by inhibiting mitochondrial depolarization independently of its free radical scavenging property
L Papucci, N Schiavone, E Witort, M Donnini… - Journal of Biological …, 2003 - ASBMB
The permeability transition pore (PTP) is a mitochondrial channel whose opening causes
the mitochondrial membrane potential (ΔΨ) collapse that leads to apoptosis. Some
ubiquinone analogues have been demonstrated previously to modulate the PTP open-
closed transition in isolated mitochondria and thought to act through a common PTP-binding
site rather than through oxidation-reduction reactions. We have demonstrated recently both
in vitro and in vivo that the ubiquitous free radical scavenger and respiratory chain …
the mitochondrial membrane potential (ΔΨ) collapse that leads to apoptosis. Some
ubiquinone analogues have been demonstrated previously to modulate the PTP open-
closed transition in isolated mitochondria and thought to act through a common PTP-binding
site rather than through oxidation-reduction reactions. We have demonstrated recently both
in vitro and in vivo that the ubiquitous free radical scavenger and respiratory chain …
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