Column liquid chromatographic analysis of quinine in human plasma, saliva and urine
CP Babalola, OO Bolaji, PAF Dixon… - … of Chromatography B …, 1993 - Elsevier
A new simple, selective and reproducible high-performance liquid chromatographic method
for the determination of quinine in plasma, saliva and urine is described. The ion-pair
method was carried out on a reversed-phase C 18 column, using perchlorate ion as the
counter ion and ultraviolet detection at 254 nm. Quinine was well resolved from its major
metabolite, 3-hydroxyquinine, and the internal standard, primaquine. The limit of detection
was 10 ng/ml and the recovery was greater than 90% from the three biological fluids.
for the determination of quinine in plasma, saliva and urine is described. The ion-pair
method was carried out on a reversed-phase C 18 column, using perchlorate ion as the
counter ion and ultraviolet detection at 254 nm. Quinine was well resolved from its major
metabolite, 3-hydroxyquinine, and the internal standard, primaquine. The limit of detection
was 10 ng/ml and the recovery was greater than 90% from the three biological fluids.
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