… Given the results above, we tested the effects of combined SHP2 and CXCR1/2 inhibition.
SHP099/SX682 significantly reduced (although did not eliminate) gMDSC infiltration …

… for testing RAS/ERK pathway/CXCR1/2/NKG2A inhibitor combinations in NSCLC patients. …
tested the effects of combined SHP2 and CXCR1/2 inhibition. When combined with SHP099, …

… phosphatase activity of SHP2 modulates T-cell signaling and … carcinoma (NSCLC) GEMMs
showed that SHP2 inhibition by … the combinations of SHP2 and CXCR1/2 inhibitors in the …

… , the combination of SHP2 inhibitor and CXCR2 inhibitor SX-… effects in lung cancer by
promoting CD8 + T-cell activation, … In vitro, repertaxin was found to specifically prevent CXCR1/2-…

… of non-small cell lung cancer (NSCLC), local relapses still occur … + T cell reinvigoration and
immunosuppressive tumor-associated neutrophil (TAN) inhibition via radiotherapy combined …

… , which prevented T cell infiltration and promoted tumor growth in mice 21 . In addition, …
promotes gMDSC infiltration, suggesting combined inhibition of SHP2 and CXCR2 in lung cancer …

… combination inhibition of SHP2 and CXCR1/2 may enhance antitumor T cell responses in
NSCLC … In conclusion, SHP2 could be an oncogenic gene that encourages OSCC metastases. …

… models to combination treatment with a SOS1 inhibitor (… adagrasib with SHP2 (SHP2i) or
EGFR inhibitors and correlated … -mutant NSCLC and CRC models enhances the magnitude and …

… asked if combination therapy activates classic T-cell mediated … of lung cancer, inhibition of
CXCR1 and 2 receptors in … a novel combination immunotherapy that enhances the efficacy of …

… CXCR2 and dual (CXCR1/2) inhibitors are indicated. Figure … (non-small cell lung cancer,
NSCLC), CXCR2 was shown to … genetic tumor drivers and inhibitors of CD8 T cell function. In …