… In addition, we show that KAE609 treatment results in acidification of the yeast cytosol, but
alkalinization in P. falciparum was reported previously 5 . An explanation may be that both …

… Cipargamin (KAE609) is a novel spiroindolone class drug for the treatment of malaria, …
Four of them had parasite clearance comparable to the patients without mutations. The fifth …

… of the Spiroindolone KAE609 (Cipargamin) which is currently … in identifying novel anti-malarial
drugs including KAE609 [6]. … from the results of this comparison. This indirect method of …

… showed that NITD609 as KAE609/cipargamin at single doses … rate slower than cipargamin,
comparable with the parasite … spiroindolone derivative NITD609/KAE609/ cipargamin [17]. …

… antimalarial drugs induce rigidification of infected red blood cells. Cipargamin, a new
spiroindolone … latter model, the ED 90 of ACT-451840 is comparable to that of chloroquine (ED 90 …

… to reduce the overall impact of malaria in endemic regions, the … to support malaria elimination
and/or eradication efforts. … as promising targets for malaria chemotherapy, this study aimed …

… for treating malaria. Also, once chemically validated, the protein targets identified in this
work can serve as suitable starting points for target-based antimalarial drug discovery efforts. …

… show that NITD fast-acting leads belonging to spiroindolone … for resistance, spiroindolone
KAE609 was proposed to target … By direct comparison with DHA and spiroindolones, we show …

… Metabolite M18 had a 2 Da higher mass than KAE609, indicative of an … set the stereochemistry
of the spiroindolone system. … Route comparison When comparing the initial racemic route …

… Cipargamin (also known as KAE609) presents another promising non-ART treatment option
10 . This spiroindolone … falciparum malaria, single doses of up to 50 or 150 mg cipargamin …