[PDF][PDF] Comparative effects of methylprednisolone and tetracosactide (ACTH1–24) on ischemia/reperfusion injury of the rabbit spinal cord
Archives of Medical Science, 2018•termedia.pl
Results After ischemia-reperfusion injury, increments were found in the tissue
myeloperoxidase levels (p< 0.001), malondialdehyde levels (p< 0.001), xanthine oxidase
action (p< 0.001) and caspase-3 movement (p< 0.001). Conversely, both serum and tissue
catalase levels were diminished (p< 0.001 for both). After the administration of
tetracosactide, declines were seen in the tissue myeloperoxidase levels (p< 0.001),
malondialdehyde levels (p= 0.003), xanthine oxidase action (p< 0.001) and caspase-3 …
myeloperoxidase levels (p< 0.001), malondialdehyde levels (p< 0.001), xanthine oxidase
action (p< 0.001) and caspase-3 movement (p< 0.001). Conversely, both serum and tissue
catalase levels were diminished (p< 0.001 for both). After the administration of
tetracosactide, declines were seen in the tissue myeloperoxidase levels (p< 0.001),
malondialdehyde levels (p= 0.003), xanthine oxidase action (p< 0.001) and caspase-3 …
Results
After ischemia-reperfusion injury, increments were found in the tissue myeloperoxidase levels (p< 0.001), malondialdehyde levels (p< 0.001), xanthine oxidase action (p< 0.001) and caspase-3 movement (p< 0.001). Conversely, both serum and tissue catalase levels were diminished (p< 0.001 for both). After the administration of tetracosactide, declines were seen in the tissue myeloperoxidase levels (p< 0.001), malondialdehyde levels (p= 0.003), xanthine oxidase action (p< 0.001) and caspase-3 movement (p< 0.001). Conversely, both the serum and tissue catalase levels were expanded (p< 0.001). Besides, tetracosactide treatment indicated enhanced results related to the histopathological scores (p< 0.001), the ultra-structural score (p= 0.008) and the Tarlov scores (p< 0.001).
Conclusions
The findings showed for the first time that tetracosactide shows significant neuroprotective activity against ischemia-reperfusion injury of the spinal cord.
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