[HTML][HTML] Comparative study of endoscopic surveillance in hereditary diffuse gastric cancer according to CDH1 mutation status
EZ Mi, EZ Mi, M di Pietro, M O'Donovan… - Gastrointestinal …, 2018 - Elsevier
Background and Aims Hereditary diffuse gastric cancer (HDGC) accounts for 1% of gastric
cancer cases. For patients with a germline CDH1 mutation, risk-reducing gastrectomy is
recommended. However, for those delaying surgery or for families with no causative
mutation identified, regular endoscopy is advised. This study aimed to determine the yield of
signet ring cell carcinoma (SRCC) foci in individuals with a CDH1 pathogenic variant
compared with those without and how this varies with successive endoscopies. Methods …
cancer cases. For patients with a germline CDH1 mutation, risk-reducing gastrectomy is
recommended. However, for those delaying surgery or for families with no causative
mutation identified, regular endoscopy is advised. This study aimed to determine the yield of
signet ring cell carcinoma (SRCC) foci in individuals with a CDH1 pathogenic variant
compared with those without and how this varies with successive endoscopies. Methods …
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