Comparison between gadolinium-enhanced 2D T1-weighted gradient-echo and spin-echo sequences in the detection of active multiple sclerosis lesions on 3.0 T MRI
FX Aymerich, C Auger, P Alcaide-Leon, D Pareto… - European …, 2017 - Springer
FX Aymerich, C Auger, P Alcaide-Leon, D Pareto, E Huerga, JF Corral, R Mitjana…
European radiology, 2017•SpringerObjectives To compare the sensitivity of enhancing multiple sclerosis (MS) lesions in
gadolinium-enhanced 2D T1-weighted gradient-echo (GRE) and spin-echo (SE) sequences,
and to assess the influence of visual conspicuity and laterality on detection of these lesions.
Methods One hundred MS patients underwent 3.0 T brain MRI including gadolinium-
enhanced 2D T1-weighted GRE and SE sequences. The two sets of contrast-enhanced
scans were evaluated in random fashion by three experienced readers. Lesion conspicuity …
gadolinium-enhanced 2D T1-weighted gradient-echo (GRE) and spin-echo (SE) sequences,
and to assess the influence of visual conspicuity and laterality on detection of these lesions.
Methods One hundred MS patients underwent 3.0 T brain MRI including gadolinium-
enhanced 2D T1-weighted GRE and SE sequences. The two sets of contrast-enhanced
scans were evaluated in random fashion by three experienced readers. Lesion conspicuity …
Objectives
To compare the sensitivity of enhancing multiple sclerosis (MS) lesions in gadolinium-enhanced 2D T1-weighted gradient-echo (GRE) and spin-echo (SE) sequences, and to assess the influence of visual conspicuity and laterality on detection of these lesions.
Methods
One hundred MS patients underwent 3.0T brain MRI including gadolinium-enhanced 2D T1-weighted GRE and SE sequences. The two sets of contrast-enhanced scans were evaluated in random fashion by three experienced readers. Lesion conspicuity was assessed by the image contrast ratio (CR) and contrast-to-noise ratio (CNR). The intracranial region was divided into four quadrants and the impact of lesion location on detection was assessed in each slice.
Results
Six hundred and seven gadolinium-enhancing MS lesions were identified. GRE images were more sensitive for lesion detection (0.828) than SE images (0.767). Lesions showed a higher CR in SE than in GRE images, whereas the CNR was higher in GRE than SE. Most misclassifications occurred in the right posterior quadrant.
Conclusions
The gadolinium-enhanced 2D T1-weighted GRE sequence at 3.0T MRI enables detection of enhancing MS lesions with higher sensitivity and better lesion conspicuity than 2D T1-weighted SE. Hence, we propose the use of gadolinium-enhanced GRE sequences rather than SE sequences for routine scanning of MS patients at 3.0T.
Key Points
• 2D SE and GRE sequences are useful for detecting active MS lesions.
• Which of these sequences is more sensitive at high field remains uncertain.
• GRE sequence showed better sensitivity for detecting active MS lesions than SE.
• We propose GRE sequence for detecting active MS lesions at 3.0T.
Springer
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