Comparison of various responses such as fill time, deflection, volumetric shrinkage and residual stress between runner linear layout and runner star layout using mold flow simulation software in family plastic injection molding was studied. The plastic parts such as tensile specimen, impact specimen, flexural specimen and hardness specimen were designed using CATIA version 5. Then, designed plastic parts in CATIA software were imported into Moldflow software to transform the plastic specimen parts from solid form to mesh form. Feeding system such as sprue, runner and gate including water cooling system was designed inside the mold. Determination of the type of injection molding machine and the type of plastic material in the settings was taking under cool+ fill+ pack+ warp analysis. It is found that runner linear layout produces lower filling time as compared to runner star layout and deflection on runner linear layout was lower than runner star layout. Then, shrinkage value in runner star layout exceeded runner linear layout. In addition, in cavity residual stress, distribution stress on the plastic part surface of the star runner layout shows high stress. Thus, it shows that runner linear layout in family plastic injection molding was the most suitable layout for this family injection mold.