Bats are known to be the reservoir of various zoonotic viruses that are fatal to humans. The role of bats as a viral reservoir is supported by the uniqueness of bat's immune (Baker & Zhou 2015) as well as the uniqueness of the bat's ecological character (Wang et al. 2011). Bat ability to fly is one of the keys that is expected to support the resilience of bats against viral infections (O'Shea et al. 2014). Despite the high rate of metabolism due to its flying ability, bats have a long life span whichapproximately can reach 35 years (Calisher et al. 2006). High metabolism demands high oxygen consumption thus increasing the formation of free radical reactive oxygen species (ROS). However, based on free radical theory of aging, the cumulative formation of ROS can lead to oxidative stress that have deletarious effects and reduce life span (Harman 2006). The study of oxidative stress state in bats as a viral reservoir and having a long life span is interesting to study. This study examined the comparison of oxidative stress status in the spleen and liver betweenthe Lesser Short Nosed Bat (Cynopterus brachyotis) which has long life span and laboratory rats (Rattus norvegicus) which has shortlife span. The ROS-forming indicator was measured with malonaldehyde (MDA) parameter while the measured antioxidant parameter was super oxide dismutase (SOD).