… comparison to insulin monotherapy with premixed insulin (15–17). In the present study, insulin
treatment initiated by adding insulin … glycemic control compared with 70/30 insulin alone. …

… antidiabetic agents. The objective of this study was to find the … adding Glargine insulin to
TypeII diabetes insufficiently controlled by oral agents in comparisons to twice daily mixed insulin…

… be achieved or maintained with oral agents, the addition of insulin therapy is a … the first
direct comparison of glycaemic response between a regimen containing a twice-daily insulin …

… Switching to twice-daily premixed insulin is an alternative, … is stepwise addition of prandial
to basal insulin, beginning with … , BMI and oral agent combination for incidence comparison, …

… to add one more injection to improve glycaemic control. We … The initial total daily insulin
dose for the basal-bolus group … patients were taking oral antidiabetic medication when they …

… In addition, secondary objectives included the percentage of participants who … premixed
insulin twice daily or prandial insulin thrice daily. In this study the HbA1c at the end of the first …

… for the first prandial injection in basal-plus studies, differences … , insulin glulisine once or
twice daily was non-inferior to … receiving basal insulin, sequential addition of prandial insulin, …

… oral antihyperglycemic medications, a common starting insulin regimen consists of basal or
premixed insulin added … In the studies that compared twice-daily premixed insulin analogues …

… insulin are added to basal insulin; or (2) the use of once- or twice-daily premix insulin analogs,
which contain both basal … is the first part of stepwise intensification toward the full basal–…

… is the first comparison made between premixed insulin and … sulfonylurea, adding a once-daily
injection of insulin glargine is … starting twice-daily injections of premixed insulin without oral …