Comparison of binding ability and location of two mesoporphyrin derivatives in liposomes explored with conventional and site-selective fluorescence spectroscopy

D Veres, B Bőcskei-Antal, I Voszka… - The Journal of …, 2012 - ACS Publications
Application of porphyrins as photosensitizers is based on their light-triggered generation of
reactive oxygen species (ROS) that may cause oxidative tissue damage and ultimately kill
cells. Cellular membranes are the action grounds of many sensitizers due to their
hydrophobic or amphiphilic character as well as the location of many of the targets attacked
by ROS. Hence, the binding ability and location of porphyrins in liposomes as simple models
of cellular membranes are of outstanding interest. Here we compare mesoporphyrin IX …

Comparison of Binding Ability and Location of Two Mesoporphyrin Derivatives in Liposomes by Conventional and Site-Selective Fluorescence Spectroscopy

D Veres, B Böcskei-Antal, I Voszka, K Módos, G Csík… - Biophysical …, 2012 - cell.com
Application of porphyrins as photosensitizers is based on their light-triggered generation of
reactive oxygen species (ROS) that may cause oxidative damages and ultimately kill cells.
Cellular membranes are the action grounds of many sensitizers due to their hydrophobic or
amphyphilic character as well as the location of many of the targets attacked by ROS.
Hence, the binding ability and location of porphyrins in liposomes as simple models of
cellular membranes are of outstanding interest. Here we compare mesoporphyrin IX …
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