OBJECTIVE: To compare tubal patency by using hysterosalpingography (HSG) in women
with unruptured ectopic tubal pregnancy who were treated with either single-dose or
multiple-dose methotrexate (MTX) regimen. DESIGN: A case series with a retrospective
statistical analysis. SETTING: Maternity and teaching hospital in Turkey. PATIENT (S): Sixty-
one patients treated with MTX therapy for unruptured tubal ectopic pregnancy.
INTERVENTION (S): Thirty-one patients received single-dose and 30 multiple-dose MTX …

Results: The frequencies of ipsilateral tubal obstruction were 12 (30%) and 3 (7.5%) in the
patients who had received multiple-doses of methotrexate and single-dose methotrexate
respectively. Also, 33 (82.5%) patients in the single-dose methotrexate group and 18 (45%)
patients in the multiple-dose methotrexate group did not have bilateral obstruction. There
was a significant difference in the frequencies of tubal obstruction between the two groups
treated with single and multiple doses of methotrexate (P< 0.05). Conclusion: The incidence …