Entrepreneurship is one of the factors affecting the growth of economies worldwide. Hence, the growth of the entrepreneurship rate will be one of the concerns of policymakers in today’s societies. In order to study the factors affecting the growth of entrepreneurship rate, this fact that the attitude of individuals and the method they consider for launching a business varies from person to person is obvious. Since the opportunity-based and necessity-based entrepreneurial activities are two different attitudes in the business initiation, so, the purpose of this study is to demonstrate the existence of a significant difference in these indicators across developed and underdeveloped societies. Hence, using the dataset gathered by the Global Entrepreneurship Monitor (GEM) in 2015, this article tried to analyze the difference in the opportunity-based and necessity-based entrepreneurship rates in the factor-driven, efficiency-driven, and innovation-driven economies across the GEM member countries. As well as, with respect to the type and size of samples, the appropriate methods have been applied to reach reliable results. To compare the mean values of different groups, depending on sample size and parametric or nonparametric conditions, the ANOVA methods are being used. To this end, the Least Significant Difference (LSD), and the Wilcoxon method were the statistical ways to demonstrate the significant difference between the subgroups made by the GEM member countries. As a matter of fact, this study methodically showed that the opportunity-based entrepreneurship, as opposed to the necessity-driven entrepreneurship, in innovation-driven economies is more than in factor-driven economies. As a result, this study refers to the importance of motivation in launching efficient businesses.