Confirming that synaptic loss is directly related to cognitive deficit in Alzheimer's disease
(AD) has been the focus of many studies. Compensation mechanisms counteract synaptic
loss and prevent the catastrophic amnesia induced by synaptic loss via maintaining the
activity levels of neural circuits. Here we investigate the interplay between various synaptic
degeneration and compensation mechanisms, and abnormal cortical oscillations based on
a large-scale network model consisting of 100,000 neurons exhibiting several cortical firing …

Alzheimer's disease (AD) is the most common neurodegenerative disorder associated with
progressive dementia. The clinical symptoms of AD are cognitive and intellectual deficits
and behavior dysfunction. EEG has been utilized for diagnosing dementias. There is a
strong correlation between cognitive deficit and the degree of the EEG abnormality. EEG
spectral analysis in AD patients has shown a decrease in the mean frequency, alpha (8–12
Hz) and beta (13–30 Hz) band powers with a parallel increase in delta (1–3 Hz) and theta (4 …