Complement receptor 1 is the host erythrocyte receptor for Plasmodium falciparum PfRh4 invasion ligand
Plasmodium falciparum is responsible for the most severe form of malaria disease in
humans, causing more than 1 million deaths each year. As an obligate intracellular parasite,
P. falciparum's ability to invade erythrocytes is essential for its survival within the human
host. P. falciparum invades erythrocytes using multiple host receptor–parasite ligand
interactions known as invasion pathways. Here we show that CR1 is the host erythrocyte
receptor for PfRh4, a major P. falciparum ligand essential for sialic acid–independent …
humans, causing more than 1 million deaths each year. As an obligate intracellular parasite,
P. falciparum's ability to invade erythrocytes is essential for its survival within the human
host. P. falciparum invades erythrocytes using multiple host receptor–parasite ligand
interactions known as invasion pathways. Here we show that CR1 is the host erythrocyte
receptor for PfRh4, a major P. falciparum ligand essential for sialic acid–independent …
Complement receptor 1 is the host erythrocyte receptor for Plasmodium falciparum PfRh4 invasion ligand.
TWH Tham WaiHong, DW Wilson, S Lopaticki… - 2010 - cabidigitallibrary.org
Plasmodium falciparum is responsible for the most severe form of malaria disease in
humans, causing more than 1 million deaths each year. As an obligate intracellular parasite,
P. falciparum's ability to invade erythrocytes is essential for its survival within the human
host. P. falciparum invades erythrocytes using multiple host receptor-parasite ligand
interactions known as invasion pathways. Here we show that CR1 is the host erythrocyte
receptor for PfRh4, a major P. falciparum ligand essential for sialic acid-independent …
humans, causing more than 1 million deaths each year. As an obligate intracellular parasite,
P. falciparum's ability to invade erythrocytes is essential for its survival within the human
host. P. falciparum invades erythrocytes using multiple host receptor-parasite ligand
interactions known as invasion pathways. Here we show that CR1 is the host erythrocyte
receptor for PfRh4, a major P. falciparum ligand essential for sialic acid-independent …