Complex formation between two biosynthetic enzymes modifies the allosteric regulatory properties of both: an example of molecular symbiosis
NJ Blackmore, AR Nazmi, RD Hutton… - Journal of Biological …, 2015 - ASBMB
Allostery, where remote ligand binding alters protein function, is essential for the control of
metabolism. Here, we have identified a highly sophisticated allosteric response that allows
complex control of the pathway for aromatic amino acid biosynthesis in the pathogen
Mycobacterium tuberculosis. This response is mediated by an enzyme complex formed by
two pathway enzymes: chorismate mutase (CM) and 3-deoxy-d-arabino-heptulosonate 7-
phosphate synthase (DAH7PS). Whereas both enzymes are active in isolation, the catalytic …
metabolism. Here, we have identified a highly sophisticated allosteric response that allows
complex control of the pathway for aromatic amino acid biosynthesis in the pathogen
Mycobacterium tuberculosis. This response is mediated by an enzyme complex formed by
two pathway enzymes: chorismate mutase (CM) and 3-deoxy-d-arabino-heptulosonate 7-
phosphate synthase (DAH7PS). Whereas both enzymes are active in isolation, the catalytic …
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