[HTML][HTML] Computational analysis of antibody dynamics identifies recent HIV-1 infection

KE Seaton, NA Vandergrift, AW Deal, W Rountree… - JCI insight, 2017 - ncbi.nlm.nih.gov
… The analysis includes the presence or absence of the response along with … antibody response
when present. We evaluated plasma from 70 recent and 66 longstanding HIV-1 infections (…

[PDF][PDF] Computational analysis of antibody dynamics identifies recent HIV-1 infection

JB Rountree, NA Vandergrift, X Shen, NL Yates… - scholar.sun.ac.za
… The analysis includes the presence or absence of the response along with … antibody response
when present. We evaluated plasma from 70 recent and 66 longstanding HIV-1 infections (…

Computational discovery of novel HIV-1 entry inhibitors based on potent and broad neutralizing antibody VRC01

AM Andrianov, IA Kashyn, AV Tuzikov - Journal of Molecular Graphics and …, 2015 - Elsevier
dynamics and binding free energy calculations. The calculations identified six molecules
exhibiting a high affinity to the HIV-1 … of gp120 critical for the HIV-1 binding to cellular receptor …

A mechanistic understanding of allosteric immune escape pathways in the HIV-1 envelope glycoprotein

A Sethi, J Tian, CA Derdeyn, B Korber… - PLoS computational …, 2013 - journals.plos.org
… a network analysis-based approach to identify potential … analyses of molecular dynamics
(MD) simulations identified a … that HIV-1 uses to shield vulnerable antibody targets in Env that …

Integrated single-cell analysis of multicellular immune dynamics during hyperacute HIV-1 infection

SW Kazer, TP Aicher, DM Muema, SL Carroll… - Nature medicine, 2020 - nature.com
… Here, we present an experimental and computational … in participant 1 (P1), we identified a
set of six spanning multiple cell … contains information on the sample preparation, antibodies, …

Predicting in vivo escape dynamics of HIV-1 from a broadly neutralizing antibody

M Meijers, K Vanshylla, H Gruell… - Proceedings of the …, 2021 - National Acad Sciences
… for treatment and prevention of HIV-1 infections. Such … We identify two fitness factors, antibody
dosage and viral load, … Computational methods based on deep mutational scanning (18), …

Tracking HIV-1 recombination to resolve its contribution to HIV-1 evolution in natural infection

H Song, EE Giorgi, VV Ganusov, F Cai… - Nature …, 2018 - nature.com
… a novel computational tool (RAPR (Recombination Analysis … We identify recombination
hot and cold spots that differ from … in studies that looked at in vivo HIV-1 infection. PCR-derived …

Longitudinal analysis of HIV-1-specific antibody responses

KA Curtis, MS Kennedy, SM Owen - AIDS research and human …, 2014 - liebertpub.com
… Laboratory assays for determining recent HIV-1 infection are of great public health … chronic
infection makes the antibody subclass an attractive biomarker for identifying recent infection. …

Extended antibody-framework-to-antigen distance observed exclusively with broad HIV-1-neutralizing antibodies recognizing glycan-dense surfaces

M Lee, A Changela, J Gorman, R Rawi… - Nature …, 2021 - nature.com
… by molecular dynamics simulations of the HIV-1-envelope … potent broadly neutralizing
antibodies thus far identified; despite … The computational time spent ~1 s with one core of CPU, 2.4 …

Revealing viral and cellular dynamics of HIV-1 at the single-cell level during early treatment periods

F Otte, Y Zhang, J Spagnuolo, A Thielen, M Däumer… - Cell Reports …, 2023 - cell.com
… After primary HIV-1 infection, a founding population of viruses and virus-infected cells is
rapidly established and expanded in various body compartments. The proviral landscape is …