[引用][C] Computational analysis of interactions between anti-epileptic drugs and important placental proteins-A possible route for neural tube defects in humans

S Vijayasri, H Archana, A Agrawal, W Hopper - Int J Pharm Pharm Sci, 2016

[PDF][PDF] COMPUTATIONAL ANALYSIS OF INTERACTIONS BETWEEN ANTI-EPILEPTIC DRUGS AND IMPORTANT PLACENTAL PROTEINS-A POSSIBLE ROUTE …

HA SANTHANAM VIJAYASRI, A AGRAWAL… - 2016 - academia.edu
Objective: The reason behind the occurrence of Neural Tube Defects (NTDs) in pregnant
women treated with certain Anti-Epileptic Drugs (AEDs) such as Carbamazepine, Valproate,
Lamotrigine, Phenobarbital, etc., is not yet known. The relationship between Folic Acid
intake and NTDs is not yet established. Folate receptors play a critical role in mediating
placental transport of maternal folate to the foetus. Another important protein is Carnitine O-
acetyltransferase that is involved in the transport of carnitine, which is much needed for …
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