Computational and experimental elucidation of Plasmodium falciparum phosphoethanolamine methyltransferase inhibitors: Pivotal drug target
Introduction Plasmodium falciparum synthesizes phosphatidylcholine for the membrane
development through serine decarboxylase–phosphoethanolamine methyltransferase
pathway for growth in human host. Phosphoethanolamine-methyltransferase (Pf PMT) is a
crucial enzyme for the synthesis of phosphocholine which is a precursor for
phosphatidylcholine synthesis and is considered as a pivotal drug target as it is absent in
the host. The inhibition of Pf PMT may kill malaria parasite and hence is being considered as …
development through serine decarboxylase–phosphoethanolamine methyltransferase
pathway for growth in human host. Phosphoethanolamine-methyltransferase (Pf PMT) is a
crucial enzyme for the synthesis of phosphocholine which is a precursor for
phosphatidylcholine synthesis and is considered as a pivotal drug target as it is absent in
the host. The inhibition of Pf PMT may kill malaria parasite and hence is being considered as …
Computational and experimental elucidation of Plasmodium falciparum phosphoethanolamine methyltransferase inhibitors: pivotal drug target.
JS Jagbir Singh, SV Sonam Vijay, RM Rani Mansuri… - 2019 - cabidigitallibrary.org
Introduction: Plasmodium falciparum synthesizes phosphatidylcholine for the membrane
development through serine decarboxylase-phosphoethanolamine methyltransferase
pathway for growth in human host. Phosphoethanolamine-methyltransferase (Pf PMT) is a
crucial enzyme for the synthesis of phosphocholine which is a precursor for
phosphatidylcholine synthesis and is considered as a pivotal drug target as it is absent in
the host. The inhibition of Pf PMT may kill malaria parasite and hence is being considered as …
development through serine decarboxylase-phosphoethanolamine methyltransferase
pathway for growth in human host. Phosphoethanolamine-methyltransferase (Pf PMT) is a
crucial enzyme for the synthesis of phosphocholine which is a precursor for
phosphatidylcholine synthesis and is considered as a pivotal drug target as it is absent in
the host. The inhibition of Pf PMT may kill malaria parasite and hence is being considered as …
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