Conditionally immortalized clonal cell lines from the mouse olfactory placode differentiate into olfactory receptor neurons
N Illing, S Boolay, JS Siwoski, D Casper… - Molecular and Cellular …, 2002 - Elsevier
To test extracellular signals that direct the development of the olfactory system, we have
generated clonal temperature-sensitive cell lines that represent distinct cellular lineages
derived from the E10 mouse olfactory placode. Two of these lines, OP6 and OP27, express
(at the permissive temperature), a transcriptional profile representing intermediate-late
developmental stages in the olfactory receptor neuron (ORN) lineage. At the nonpermissive
temperature, both OP6 and OP27 cells can be induced by all-trans retinoic acid to …
generated clonal temperature-sensitive cell lines that represent distinct cellular lineages
derived from the E10 mouse olfactory placode. Two of these lines, OP6 and OP27, express
(at the permissive temperature), a transcriptional profile representing intermediate-late
developmental stages in the olfactory receptor neuron (ORN) lineage. At the nonpermissive
temperature, both OP6 and OP27 cells can be induced by all-trans retinoic acid to …
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