… Cx43 confers resistance to TMZ by activating PI3K Next, we explored how Cx43 confers …
αCT1 inactivates PI3K [21], leading us to hypothesize that Cx43 activates PI3K to induce TMZ …

… Glutamate exhibits its progrowth activity through activating the downstream signaling
pathways such as PI3K or MAPK, both of which have been implicated in GBM pathogenesis (28). …

… Surgery, radiotherapy and chemotherapy are the main treatment options for cancer (1–3 ).
In … This indicates that silencing of Cx43 after irradiation activates the PI3K/AKT pathway. …

… EMT by elevating connexin (Cx) 43 expression could reverse … , via its SH3-binding domain.
c-Src has been reported to play vital roles in EMT, chemotherapy resistance and activate PI3K…

… Connexin 43 enhances paclitaxel cytotoxicity in colorectal … the regulation of the cytotoxicity
of chemotherapy agents, because, … The present study demonstrated that the PI3K/Akt pathway …

… of connexins in that expression levels and membrane localization of connexins, including
Connexin 43 (… growth, EMT and cancer cell invasion via activating PI3K/Akt pathway (Fig. 3). …

… and employed the Connexin 43 (… chemotherapy response in cancer such as glioblastoma
cells. Citation14,Citation15 It remains unclear that connexin could attenuate the chemotherapy …

… there exists a reciprocal activation between Cx26 and PI3K/Akt … in the development of
cancer chemoresistance, our results reveal a … Enhanced effect of connexin 43 on cisplatin-induced …

… Cx43 is capable of conferring chemotherapeutic resistance to … tumor resection, combinatorial
chemotherapy using TMZ is a … These data suggest a possible role for the PI3K/AKT/mTOR …

… as the chemosensitivity and radiosensitivity of … activation [47]. Interestingly, c-Src regulation
of epithelial-mesenchymal transition (EMT) via the PI3K/Akt pathway may regulate connexin …