Consensus in silico computational modelling of the p22phox subunit of the NADPH oxidase
DN Meijles, BJ Howlin, JM Li - Computational biology and chemistry, 2012 - Elsevier
The p22phox protein is an essential subunit of the cytochrome b558 of the NADPH oxidase
(Nox) complex which by generating reactive oxygen species (ROS) plays important role in
regulating cellular function. p22phox stabilises the Nox enzyme, assists in catalytic core
maturation and in the meantime provides an anchoring site for cytosolic regulatory subunits
to bind. However, the protein structure of the p22phox is still uncertain. In this study we use
an in silico computational bioinformatic approach to produce a consensus 3-dimensional …
(Nox) complex which by generating reactive oxygen species (ROS) plays important role in
regulating cellular function. p22phox stabilises the Nox enzyme, assists in catalytic core
maturation and in the meantime provides an anchoring site for cytosolic regulatory subunits
to bind. However, the protein structure of the p22phox is still uncertain. In this study we use
an in silico computational bioinformatic approach to produce a consensus 3-dimensional …
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