The median age of the patients wearing full removable dentures is rising. Their jawbones are more and more atrophied. In order to construct an efficient total prosthesis, we based on the Biofunctional System, elaborated by U. Stuttgen. The preparation process of these dentures was built on the principles of Guided Functional Movement. The aim of our study was to construct a full removable prosthesis according to the bilateral balanced occlusion with no alterations, interferences, deformities and to compare it with the conventional prosthesis in terms of stability, function, achievement of balanced occlusion, strength, mechanical resistance, decubitus, sore and aesthetics. As a study material, we included 245 patients treated by our University Clinic, at the Department of Prosthodontic, observed in 7 years long period. We divided patients into two groups: in the first one 133 patients treated by using biofunctional prosthesis and 112 patients were part of the second group treated with the conventional dentures. We concluded and compared the results of the prosthesis systems in both groups based on the check up immediately after putting on the dentures and 7 years later. As a result, the biofunctional prosthesis had a high advantage compared to the conventional ones in all terms.