Construction of a versatile and functional nanoparticle platform derived from a helical diblock copolypeptide-based biomimetic polymer

J Fan, R Li, X He, K Seetho, F Zhang, J Zou… - Polymer …, 2014 - pubs.rsc.org
Polymer chemistry, 2014pubs.rsc.org
Sequential polymerization of N-carboxyanhydrides accelerated by nitrogen flow is utilized to
generate a novel well-defined diblock copolypeptide (PDI= 1.08), with incorporation of
alkyne-functionalized side-chain groups allowing for rapid and efficient thiol–yne click-type
modifications, followed by self-assembly into nanopure water to construct a helical
polypeptide-based versatile and functional nanoparticle platform.
Sequential polymerization of N-carboxyanhydrides accelerated by nitrogen flow is utilized to generate a novel well-defined diblock copolypeptide (PDI = 1.08), with incorporation of alkyne-functionalized side-chain groups allowing for rapid and efficient thiol–yne click-type modifications, followed by self-assembly into nanopure water to construct a helical polypeptide-based versatile and functional nanoparticle platform.
The Royal Society of Chemistry
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